Platelet Alloantigen Polymorphism and Migraine Headache - An Observation in the Malaysian Population at Kelantan
نویسنده
چکیده
Migraine is a common disabling disorder characterized by recurrent headaches and at times non-painful episodic phenomena associated with a variety of neurological manifestations. It ranks among the top 20 causes of disability worldwide [1]. It therefore has a substantial impact on individuals as well as on society. A community based study on headaches in Malaysia showed the prevalence of migraine to be 9% in the population [2]. Evidence to support that genetic factors are involved in migraine, especially in migraine with aura has accumulated during the past few years [3]. First-degree relatives of probands who have migraine with aura have a four-fold increased risk of migraine (with aura).
منابع مشابه
Gene frequencies of human platelet alloantigens in Kelantan, Malaysia.
The gene for the ß 3 (GPIIIa) subunit of the integrin α IIb ß 3 (GPIIb-IIIa) present on the platelet membrane contains the platelet antigen alleles (PlA) in a homozygous form (Pl/) or the heterozygous or polymorphic form (Pl/) in humans. This GPIIIa subunit serves as a receptor for adhesive proteins (viz. fi brinogen and von Willebrand factor) and is critical for platelet aggregation. The struc...
متن کاملRamadan bazaar and Ramadan buffets: The possible influence on eating behavior and health among Malaysian Muslims
Ramadan is one of the special months for Muslims all over the world. During Ramadan, able‐bodied Muslims are abstained from eating, drinking and even smoking from dawn to sunset. In Malaysia, the duration of fasting are normally around 13 hours at any time of the year as it is located near the equator. The altered food intake timing and long period of fasting do influence on eating behavior of ...
متن کاملTolerability and efficacy of memantine as add on therapy in patients with refractory migraine
Prophylactic migraine treatment has always been a challenge. Efficacy and tolerability are two main issues in current approved migraine prevention regimens. Since some migraineurs patients fail approved preventative agents, experts are always seeking newer agents. Memantine, a glutaminergic antagonist, could potentially be one of these agents. Objective of current study is assessing the efficac...
متن کاملTolerability and efficacy of memantine as add on therapy in patients with refractory migraine
Prophylactic migraine treatment has always been a challenge. Efficacy and tolerability are two main issues in current approved migraine prevention regimens. Since some migraineurs patients fail approved preventative agents, experts are always seeking newer agents. Memantine, a glutaminergic antagonist, could potentially be one of these agents. Objective of current study is assessing the efficac...
متن کامل